IMPACT OF THE CORONA PANDEMIC ON THE DEMOGRAPHIC STRUCTURE IN AUSTRIA

The COVID-19 pandemic and the policy measures imposed to contain the virus affected people's health and lifestyles. Based on data available to the Federal Agency "Statistics Austria”, this paper asks about the impact of the pandemic years 2020 and 2021 (and partly beyond) on the Austrian demographics and population. It shows that mortality increased significantly during this period but varied by waves of infection also with the introduction of different policy measures (e.g., lockdowns). There are also changes in the number of births over the course of the pandemic, which can be interpreted through insecurities related to lockdowns and vaccinations. People who wanted to marry or get divorced during the pandemic years were confronted with closed offices and restrictions on holding celebrations, which is why there were significantly fewer marriages and divorces. International migration dropped significantly, especially in the spring of 2020, when European and global mobility was severely restricted, with differences between people of different nationalities. This was also reflected in the number of asylum applications filed in Austria. Migrations within Austria were strongly reduced during the first lockdown in 2020, all further lockdowns had less influence on them. However, in 2020 and 2021 there were several phases in which more people moved from urban to rural areas than before the pandemic. The number of registered secondary residences – which took on new relevance in the context of mobility restrictions and the use of home offices – also changed: overall, their number increased during the pandemic, but in many municipalities, deregistrations of seasonal workers were also noticeable. © 2022 Austrian Geographical Society. All rights reserved.

A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded Trial of Efficacy and Safety of Riluzole in Acute Spinal Cord Injury Study (RISCIS)

INTRODUCTION: Riluzole, a sodium-glutamate antagonist which is FDA approved for ALS has shown promising pre-clinical results and is clinically safe in SCI patients. METHOD(S): The RISCIS trial is an international, multi-center, prospective, double-blinded, randomized, placebo-controlled Phase II/ III trial. Patients with ASIA A-C, C4-C8 SCI and <12 hours from injury were randomized between Riluzole, at an oral dose of 100mg BID for the first 24 hours followed by 50mg BID for the following 13 days, and placebo control. RESULT(S): Due to the impact of the global COVID-19 pandemic this trial was terminated prior to completion. 193 patients were randomized with a follow-up rate of 82.7% at 180-days. No statistical difference was noted in the demographics and baseline injury characteristics between the two groups. At 6 months there was a median gain in total motor scores (TOTM) of 30.0 in the Riluzole group compared to 20.0 for the Placebo group. The improved motor outcomes did not reach statistical significance. Given the decreased sample size, additional sensitivity analyses were conducted. In the ASIA-C population, Riluzole was a significant improver of total motor scores (coefficient estimate: 14.10, p = 0.020) and upper motor scores (CE: 7.68, p = 0.040) at 6 months. ASIA B patients had higher reported independence, as measured by the SCIM score (45.3 vs. 27.3;p = 0.071) and change in mental health scores as measured by the SF-36 mental health domain (2.01 vs. -11.58;p: 0.0205) at 180 days. CONCLUSION(S): Despite the premature termination of the RISCIS trial due to the COVID-19 pandemic, 193 subjects were recruited into this trial. Primary analysis showed a 10-motor point gain in riluzoletreated subjects which did not reach significance. However, on secondary analysis, incomplete cervical SCI subjects (AIS B and C) showed significant gains in functional recovery.

Frequencies of Adenovirus Types in U.S. Children with Acute Respiratory Illness, 2016-2019

Background. Adenovirus (AdV) is a common cause of acute respiratory illness (ARI). Multiple respiratory AdV types have been identified in humans, but it remains unclear which are the most common in U.S. children with ARI. Methods. We conducted a multicenter, prospective viral surveillance study at seven U.S. children's hospitals, the New Vaccine Surveillance Network, during 12/1/ 16-11/30/19, prior to the COVID-19 pandemic. Children < 18 years of age seen in the emergency department or hospitalized with fever and/or respiratory symptoms were enrolled, and mid-turbinate nasal +/- throat swabs were tested using multiplex respiratory pathogen assays or real time polymerase chain reaction (PCR) test for AdV, respiratory syncytial virus (RSV), human metapneumovirus, rhinovirus/enterovirus (RV), influenza, parainfluenza viruses, and endemic coronaviruses. AdV-positive specimens were subsequently typed using single-plex qPCR assays targeting sequences in the hexon gene specific for types 1-7, 11, 14, 16 and 21. Demographics, clinical characteristics, and outcomes were compared between AdV types. Results. Of 29,381 enrolled children, 2,106 (7.2%) tested positive for AdV. The distribution of types among the 1,330 (63.2%) successfully typed specimens were as follows: 31.7% AdV-2, 28.9% AdV-1, 15.3% AdV-3, 7.9% AdV-5, 5.9% AdV-7, 1.4% AdV-4, 1.2% AdV-6, 0.5% AdV-14, 0.2% AdV-21, 0.1% AdV-11, and 7.0% >=1 AdV type. Most children with AdV-1 or AdV-2 detection were < 5 years of age (Figure 1a). Demographic and clinical characteristics varied by AdV types, including age, race/ethnicity, smoke exposure, daycare/school attendance, and hospitalization (Table 1). Co-detection with other viruses was common among all AdV types, with RV and RSV being the most frequently co-detected (Figure 1b). Fever and cough were the most common symptoms for all AdV types (Figure 2). Children with AdV-7 detected as single pathogen had higher odds of hospitalization (adjusted odds ratio 6.34 [95% CI: 3.10, 12.95], p= 0.027). Conclusion. AdV-2 and AdV-1 were the most frequently detected AdV types among children over the 3-year study period. Notable clinical heterogeneity of the AdV types warrants further surveillance studies to identify AdV types that could be targeted for pediatric vaccine development. (Figure Presented).

Circulation of Rhinovirus/Enterovirus Respiratory Infections in Children during 2020-21 in the United States

Background. Sharp declines in influenza and respiratory syncytial virus (RSV) circulation across the U.S. have been described during the pandemic in temporal association with community mitigation for control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to determine relative frequencies of rhinovirus/ enterovirus (RV/EV) and other respiratory viruses in children presenting to emergency departments or hospitalized with acute respiratory illness (ARI) prior to and during the COVID-19 pandemic. Methods. We conducted a multi-center active prospective ARI surveillance study in children as part of the New Vaccine Surveillance Network (NVSN) from December 2016 through January 2021. Molecular testing for RV/EV, RSV, influenza, and other respiratory viruses [i.e., human metapneumovirus, parainfluenza virus (Types 1-4), and adenovirus] were performed on specimens collected from children enrolled children. Cumulative percent positivity of each virus type during March 2020-January 2021 was compared from March-January in the prior seasons (2017-2018, 2018-2019, 2019-2020) using Pearson's chi-squared. Data are provisional. Results. Among 69,403 eligible children, 37,676 (54%) were enrolled and tested for respiratory viruses. The number of both eligible and enrolled children declined in early 2020 (Figure 1), but 4,691 children (52% of eligible) were enrolled and tested during March 2020-January 2021. From March 2020-January 2021, the overall percentage of enrolled children with respiratory testing who had detectable RV/EV was similar compared to the same time period in 2017-2018 and 2019-2020 (Figure 1, Table 1). In contrast, the percent positivity of RSV, influenza, and other respiratory viruses combined declined compared to prior years, (p< 0.001, Figure 1, Table 1). Figure 1. Percentage of Viral Detection Among Enrolled Children Who Received Respiratory Testing, New Vaccine Surveillance Network (NVSN), United States, December 2016 - January 2021 Table 1. Percent of Respiratory Viruses Circulating in March 2020- January 2021, compared to March-January in Prior Years, New Vaccine Surveillance Network (NVSN), United States, March 2017 - January 2021 Conclusion. During 2020, RV/EV continued to circulate among children receiving care for ARI despite abrupt declines in other respiratory viruses within this population. These findings warrant further studies to understand virologic, behavioral, biological, and/or environmental factors associated with this continued RV/EV circulation.

Education in Times of Global Crisis: How Private Actors in Germany Gain Power through Twitter

The outbreak of the COVID-19 pandemic led to enormous societal changes worldwide and touched many different areas of daily life. One of the most serious restrictions to contain the pandemic was the closure of schools and kindergartens. Particularly in countries with comparatively low levels of digitalization in schools, this situation opened up opportunities for private actors to gain importance and influence in the education sector. For this article, we draw on policy network approaches and network theory to analyze Twitter discussions around digital learning and homeschooling during the period of school closures in Germany due to the COVID-19 crisis. We use social network analysis to identify the actors involved and their influences in the issue-specific Twitter communication network. In recent years, Twitter has been increasingly used for exchanges on education policy content, mainly by political and civil society actors. Our study shows that with respect to digital learning and homeschooling, it was primarily individual experts and consultants as well as corporations which influenced the discourse. In particular, it appears that Twitter is used as a forum to promote corporations' own products and platforms, including by globally operating corporations such as Microsoft and YouTube, while public actors remain barely visible.

Formalized Mentorship in Radiation Oncology: Bridging Existing Gaps in Mentorship

Purpose/Objective(s): The American College of Radiation Oncology (ACRO) Resident Committee offers a mentorship program to medical students, residents, and new practitioners. This program provides a unique opportunity to develop formal mentorship on a national level to bridge existing mentorship gaps. This abstract examined the perceived benefits of a formal mentorship program. Materials/Methods: All applicants provided demographic information and specific mentorship need requests. Pairings occurred periodically based on a personalized pairing process. This year, due to COVID-19, all sessions were held virtually. A questionnaire was designed in Google Forms based on the Society for Women in Radiation Oncology (SWRO) annual survey to evaluate the mentorship program. Data were collected and analysis was conducted using JMP version 15(SAS Institute Inc, Cary, NC). Results: Since June 2020, 78 individuals enrolled: 28 to become a mentor, 38 to become a mentee;12 were interested in both. The mentor group consisted of radiation oncology residents (47.5%), academic faculty (40%) and private practice physicians (12.5%). 57.5% of the mentors were males and 4% associated with the LGBTQI+ community. Geographic distribution of mentors: 40% Midwest, 27.5% South/Southeast, 15% Northeast, 12.5% West Coast and 5% international. Among resident mentors, 58% were Junior (PGY1-3) and 42% were senior (PGY4-5) residents. Among mentees, 50% were residents, followed by medical students (46%) and new practitioners (4%). There were equal number of males and females. The geographic distribution was: 32% Midwest, 22% South/Southeast, 36% Northeast, 2% West Coast, and 8% international. The distribution across residency training years was: 57% Junior (PGY1-3) and 43% Senior (PGY4-5). The survey was sent out in January 2021 and we currently have 29/78, 37% response rate. This survey showed the most common method of communication was email (59%), followed by video call (52%) and phone (48%). 62% had at least 2 interactions since being paired. Both parties set up the interactions in 59% of pairs, followed by mentees being responsible in 24%. Mentors reported experiencing mutual respect (94%), a personal connection (67%), clear expectations (44%), and shared values (44%). Mentees similarly reported mutual respect (94%), shared values (76%), a personal connection (59%) and clear expectations (47%). 96% had mentor/mentee relationship outside ACRO program;however, 62% felt that a formal program is more beneficial than informal opportunities. Conclusion: The results of our mentorship program highlight the continued interest and need for formal radiation oncology mentorship programs. The major strength of the program has been the high rates of interaction which is based on mutual respect, shared values and personal connection. Areas of future focus includes recruiting more new practitioners and private practice radiation oncologists to help enrich and diversify the mentorship program.

Impact assessment of the covid-19 on trade between eastern europe and china

The high-risk of the rapidly spreading COVID-19 virus worldwide created a necessity for developing a diagnostic tool designed to predict economic development, considering the risks of spreading the coronavirus epidemic. In the proposed research, China is selected strategically due to the U.S. "Buy American" trade policy. Also, the European Union presents various trade barriers for products manufactured in countries of Eastern Europe. The risk-versus-economic efficiency study is performed based on Fibonacci law utilizing trade-dynamic indicators with incorporating the SIR-model used to predict the dynamics of COVID-19 cases in the region. The research was performed based on data collected for the period of March-July 2020. As a result, a scientific model to predict the dynamics of trade volume between China and ten selected Eastern European countries is developed. The results obtained have a practical application and can be used for government institutions and economic agencies to determine their nation's short-and long-term international trade strategy. © 2020, Institute of Eastern Europe and Central Asia. All rights reserved.